The A41 at Hinstock was closed on Tuesday afternoon following a collision involving a number of vehicles.
Emergency services were called to the collision at around 2.30pm.
Shropshire Fire and Rescue Service reports the collision involves two saloon cars, two vans and two articulated lorries.
Emergency services were working at the scene with four casualties reported.
West Midlands Ambulance Service, the Midlands Air Ambulance, West Mercia Police and five fire appliances including the Rescue Tender were mobilised from Hodnet, Market Drayton, Newport and Wellington.
Motorists are being advised to use an alternative route.
Update: The road remains closed at 1pm on Wednesday.
Pump mobilised at 14:32 with @FireHodnet @NewportSfrs @SFRS_Wellington and @SFRS_CWhite in support to RTC on the #A41 at #Hinstock 🚒🚗 Multiple vehicles involved 🚚🚛💥🚙🚗 Several walking wounded casualties 🤕 Multi agency working @MDraytonCops @OFFICIALWMAS @Helistig #JESIP pic.twitter.com/dAAD0RuPdD— Market Drayton (@SFRS_MDrayton) March 3, 2020
@MAA_Charity Helimed03 with @OFFICIALWMAS @shropsfire @WMerciaPolice @SFRS_MDrayton at Hinstock. pic.twitter.com/cbtjjaYePW— Helistig (@Helistig) March 3, 2020